Toll-like Receptor Signaling : A short Review
TLR family comprises 10 members (TLR1-TLR10) in humans. TLRs recognize PAMPs such as lipid, lipoprotein, protein, and nucleic acid and localize to the surface of the cell or intracellular components such as endosome, Lysosome, ER, or endo-lysosome as a homodimer or heterodimer with a coreceptor. The ectodomain of TLR with leucine-rich repeats (LRRs) mediate PAMPs recognition while transmembrane domain and Toll/IL-1 receptor domain initiate the downstream signaling. Read more